Caffeine is the most widely available legal psychoactive stimulant drug. Also known as theine, methyltheobromine and trimethylxanthine, this xanthine alkaloid is not only found in coffee beans, but also in guaranine that is derived from guarana, mateine derived from mate, theine which is found in various teas and the kola nut, which is the base flavor of various Cola soft drinks. It stimulates the central nervous system, where it restores alertness and wards off drowsiness. Caffeine is also know to display certain diuretic properties, is an ergogenic, an atagonist of the adenosine receptors, and a cAMP levels increasing factor. It seems that caffeine helps prevent the onset of Parkinson’s disease and in the long run lowers the possibility of developing a heart disease.

Chromium Polynicotinate, which is a form of chromium, an essential trace mineral that is needed for the body's production of insulin. Insulin is a hormone that stabilizes the body's blood sugar level.

Cocoa Seed Extract is the extract of the seeds of Theobroma cacao. It is cultivated for its seeds which are present in its pod shaped fruits. The extracts from its seeds have a number of health benefits. They are also used to make chocolate. Studies show that Cocoa extracts contain a high level of flavonoids, specifically epicatechin, which may have beneficial cardiovascular effects on health. The ingestion of flavonol-rich cocoa is associated with acute elevation of circulating nitric oxide, enhanced flow-mediated vasodilatation, and augmented microcirculation. Researchers also found that consumption of Cocoa can reduce risk of cancer and can reduce elevated blood pressure.

Evodiamine, a bioactive alkaloid extract from the Evodiae Fructus plant, sometimes called Wu-Chu-Yu. Evodiamine is related to capsaicin, found in cayenne pepper. Evodiamine is a vanilloid receptor agonist, and may enhance lipolytic activity. Evodiamine has been shown to raise the body’s skin temperature and decrease core temperature, which is thought to burn calories and fat for energy.

Garcinia Cambogia- Gambooge, a subtropical version of the Garcinia genus and native to Indonesia, is the local name for garcinia cambogia. It bears a pumpkin like yellow coloured fruit, which extract, together with the rind, is in India a curry condiment. Extracts are also being used in several herbal appetite suppressants, but also in some energy providing products and supplements. In the body building community, besides the weight loss properties of garcinia cambogia, the main component, hydroxycitric acid, or HCA, seems to increase the levels of lipolysis in athletes. HCA may even prove to be more effective in combined use with carnitine and pyruvate. In India, garcinia cambogia was traditionally used to treat edema, constipation, irregular menstruation and against intestinal parasites. Further uses include combating rheumatism and bowel related troubles.

Ginger Root- Ginger is a very popular spice and has been used for culinary purposes for ages. Besides the widespread use in the cuisine of many nations, several traditional medicines, including the Indian and Chinese medicinal practices, have used this Zingiber officinale, as the Latin name goes, for its pain relieving, anti allergenic and anti inflammatory activities. Further uses have been noted for treatment of various ailments of the digestive tract, such as diarrhea and nausea, but also as general stomach settlers. While the use of the ginger root extract has been used in ginger beer and ginger ale beverages, the use as dietary supplement or component in nutritional supplement concoctions is relatively recent. The volatile oils of the ginger root extract have been noted for the antibacterial, analgesic, sedative and antipyretic properties.

Green Tea Extract, a bioflavonoid rich, potent extract used primarily for fighting free radicals. It contains a high content of polyphenols, which are a class of bioflavonoids. Green tea extract contains a potent antioxidant, EGCG, which is over 200 times more powerful than vitamin E in neutralizing the pro-oxidants and free radicals that attack lipids in the brain. Green tea extract helps with thermogenesis and aids in the metabolism of fat. Green Tea has been used for years as a powerful antioxidant, it may also be helpful in shedding fat. The most obvious benefit to dieters is that it works without increasing the heart rate most often found in diet aids. The increased heart rate leaves dieters jittery and eventually, most dieters stop using the supplement and gain weight back. Now through using green tea extract, dieters get the weight loss benefits without any of the jittery effects, especially in obese individuals with hypertension and other cardiovascular complications.

Guarana- The active constituent of guarana is caffeine, which means that it should not be used alongside ephedrine as either a dietary aid or in order to stimulate performance. The American Food and Drug Administration has not tested its effectiveness or its purity as they do not class it as a drug. Guarana has many other names including Brazilian cocoa and may be a constituent of non alcoholic drinks imported from South America. Because of possible adverse reactions it is not recommended for anyone with a heart condition or who has kidney disease, high blood pressure or who suffers from anxiety.

Hoodia Gordonii is widely thought of as an appetite suppressant; however, there have not been sufficient studies to support this theory.

Hordenine has antibacterial and antibiotic properties and is another weight loss agent that also stimulates the central nervous system.

L-Tyrosine is a non-essential amino acid, which is used by the cells in order to synthesize the proteins and appears to help stabilize ones mood during periods of high stress levels.

Octopamine is related to noradrenaline. Octopamine was discovered by Vittorio Erspamer, an Italian scientist in 1948. Octopamine has a significant role in mollusks and is the central nervous system in snail. Octopamine also has a vital role in memory and learning in the fruit fly and honey bee. Octopamine is also useful for the firefly in releasing the light production. Octopamine mobilizes releasing fat in mammals and this has developed into promotion as a slimming aid on the internet. However, there is no apparent evidence about Octopamine facilitating weight loss. Octopamine also significantly increases the blood pressure in combination with stimulants such as weight loss supplements. This is extensively used in energy demanding insects such as spiders, lobsters, crabs and crayfish as their behaviors also include egg-laying, jumping and flying. Among vertebrates, Octopamine substitutes norepinephrine and as well exhibits common side effects. Octopamine is sited in the locust jump such that it modulates the muscle activity allowing the leg muscles to contract effectively.

Pantothenic Acid, commonly called vitamin B5, is water soluble and is needed by every cell in the body to maintain good health. It helps in breaking down carbohydrates, fats and proteins to provide the body with energy. It assists in the production of red blood cells and hormones and ensures a healthy pregnancy. It is also known to lower triglyceride and cholesterol levels in the body. It helps in reducing stress and treating people with rheumatoid arthritis. Pantothenic acid is found in small quantities in almost all foods but abundantly in meats, fish, poultry, avocados, peas, broccoli and whole grains. A deficiency which is rare, leads to leg cramps, gastrointestinal problems, anemia, insomnia, depression, a burning sensation in the limbs and a weakened immune system.

Synephrine is a drug that is deemed to selectively bind to and also activate alpha adrenergic receptors. Mainly used as a vasoconstrictor in asthma, glaucoma, circulatory failure and nasal congestion, this compound is currently propagated as a weight loss agent. The alleged function synephrine is providing include fat burning, energy level and metabolism increase and promotion of weight loss. Synephrine, also known as oxedrine, is the widely accepted replacement for ephedrine. The natural source of synephrine is the citrus aurantium fruit, better known as bitter orange. Bitter orange extracts, which contain synephrine, are known to stimulate the alpha-1 adrenergic receptor, thereby constricting blood vessels and increasing the heart rate as well as blood pressure, effecting in an increased energy use.

Vinpocetine is available in capsule form. Vinpocetine has certain properties which helps move the right amount of blood to the brain from the body. It also enhances certain components of the body. The advantage of consuming this natural substance is it helps oxygen and blood flow to the brain, this helps overcome obstacles which form in the eyes. Many diagnosed with eye disorders that have an impact on the overall eyesight have successfully recovered after using this natural extract. It eliminates cognitive impairments which cause low metabolism, dangerous clots and memory loss. Ingestion of Vinpocetine seems to have a positive correlation with the healing of Tinnitus – the buzzing or ringing sensation in the ear, which is mainly caused due to the disruption of natural blood flow through the entire body. It greatly helps optimize your overall health conditions. Vinpocetine mainly contains the extract from the popular periwinkle plant.

White Willow Bark, which is often used as a natural alternative to aspirin, and is best not to be used by individuals allergic to aspirin. White willow bark extract offers little benefit to weight loss by itself but when used with other dietary supplements, it is thought to work as a thermogenic and help to elevate energy expenditure and promote the metabolsim of fat.

Yerba Matte- The plant of the yerba maté, as yerba matte is actually called, is a small tree or a shrub which can grow up to a size of fifteen meters. The leaves and twigs have traditionally been used to brew a tea like concoction, which is still a very popular social beverage in South America. Yerba maté contains alcaloids that are very similar to caffeine, commonly referred to as xanthines, but also elements like manganese, magnesium and potassium. The main difference between yerba maté and coffee, for instance, is the effect it has on muscle tissue, where it appears to relax smooth muscle tissue, but stimulate heart tissue and that is why it is used in Thermo Hydroxadrine. In other studies, yerba maté was found to work as a monoamine oxidase inhibitor, thereby professing antidepressant qualities.