Caffeine may be the most popular legal addictive stimulant that is available to mankind. Besides coffee, tea, guarana and kola nut have excess amount of this xanthine alkaloid, which is actually acting as a psychoactive drug. In several plants, caffeine is an effective insect repellant, but this trimethylxanthine is deemed by the Food and Drug Administration as generally safe food substance. It is an antagonist of adenosine receptors. The effect of caffeine is individual and may more or less increase the ability to perform physical and mental labor. It reduces the effects of fatigue and may in long term help predominantly men reduce the risk of developing Parkinson’s disease. It has also been observed that caffeine has nootropic effects, furthermore, regular consumption of caffeine may significantly reduce the risk of heart diseases.

Chromium Polynicotinate, which is a form of chromium, an essential trace mineral that is needed for the body's production of insulin. Insulin is a hormone that stabilizes the body's blood sugar level.

Cocoa Seed Extract is the extract of the seeds of Theobroma cacao. It is cultivated for its seeds which are present in its pod shaped fruits. The extracts from its seeds have a number of health benefits. They are also used to make chocolate. Studies show that Cocoa extracts contain a high level of flavonoids, specifically epicatechin, which may have beneficial cardiovascular effects on health. The ingestion of flavonol-rich cocoa is associated with acute elevation of circulating nitric oxide, enhanced flow-mediated vasodilatation, and augmented microcirculation. Researchers also found that consumption of Cocoa can reduce risk of cancer and can reduce elevated blood pressure.

Evodiamine- Tetradii Fructus, the fruit of the evodia plant, also known as Tetradium rutaecarpa, contains an active element that has recently been identified as evodiamine. This chemical compound is believed to be somewhat similar to capsaicin, the active compound found in the chili peppers. Some studies suggested that this vanilloid receptor agonist may interact with thermogenin, otherwise known as the uncoupling protein 1, UCP1, which is able to generate heat by a mechanism called thermogenesis. Tetradium rutaecarpa has been traditionally used in Chinese medicine for weight loss purposes and current studies seem to verify this information. Evodiamine has been embraced as a dietary supplement directed at weight loss, predominantly by the body building circles. This supplement is deemed to have energy burning and fat reducing, as well as diuretic properties.

Garcinia Cambogia is helpful for weight loss as it suppresses accumulation of body fats. It promotes fat oxidation, increases serotonin release and its availability in brain, normalizes lipid profiles and reduces serum leptin levels in overweight people. Garcinia cambogia extract improves mucosal defensive mechanisms in the stomach and, so, is a good protective agent against gastric ulcers. It reduces both the volume and acidity of gastric juice. It acts as an appetite suppressant and also enhances metabolism. Garcinia cambogia can be helpful for people who attempt to have a low carb diet. It helps improve energy levels and strengthen the immune system. Garcinia cambogia extract can increase mucosal defense means in stomach, thus helping with gastric ulcers. It can decrease stomach acidity, and increase defensive properties on gastric juices.

Ginger Root- Although used in cooking ginger is also used as a medicine. Medically it is a carminative, i.e. something that prevents the formation of intestinal gas, and as a stimulant, and is widely used for both colic and dyspepsia. Pregnant women are often recommended to eat ginger in the mornings in order to avoid morning sickness. It is generally safe to take although it is contraindicated in those taking Warfarin and also in those with gall stones as it can stimulate the liver’s production of bile. There is some evidence that ginger can ease arthritic pain and it is possible that it has blood thinning properties and may lower cholesterol levels

Green Tea Extract- Camellia sinensis, or more commonly the tea plant is a genus of flowering plants which is generally being used to produce tea, including green tea, oolong, black tea, white tea and pu-erh tea, also called Bolay tea. The different oxidation process makes the final difference. Tea plants can grow out into a tree, but are generally pruned to allow for easy hand picking. While camellia sinensis is being cultivated all around the globe in tropical and subtropical regions, this South and Southeast Asian native is most popular when imported from India and China. Medical uses of tea stem from the traditional Chinese medicine, where it was used as a bronchodilator and to treat angina pectoris, coronary artery disease and peripheral vascular diseases. Green tea extract is used as appetite suppressant and thermogenesis increasing agent.

Guarana is a climbing plant of the Sapindaceae family native to the Amazon basin. Guarana is best known for its fruit and seeds. Guarana extracts contain naturally high amounts of caffeine which the plant uses in defense against pathogens. Its extracts are a natural and abundant source of caffeine in most parts of the world. It is added to soft drinks, herbal tea, energy shots and used in capsules. The extracts have a positive effect on cognition and they also increase memory retention and physical endurance. A 2007 study on human pilots showed its positive effects on memory, alertness and mood. It is also reported to have antioxidant and antibacterial effects.

Hoodia Gordonii, which although popular, has no published randomized controlled trials in humans to show hoodia is safe or effective in pill form. One study published in the September 2004 issue of Brain Research found that injections of p57 (The Active ingredient in Raw, Fresh Cut Hoodia, not dried) into the appetite center of rat brains resulted in altered levels of ATP, an energy molecule that may affect hunger. The animals receiving the P57 injections also ate less than rats that received placebo injections. However, this was an animal study and INJECTIONS IN THE BRAIN are very different from oral consumption, so it cannot be used to show that oral hoodia can suppress appetite in humans. Hoodia Gordonii is a succulent (a cactus of the aloe family) found in the Kalahari desert of South Africa. Most Hoodia Gordonii products contain very little, if any of the active ingredient needed to suppress hunger. Real Hoodia is very rare and is even an endangered plant. Most importantly, Hoodia has only demonstrated any effect in fresh, raw pieces of the plant. The effectiveness of powdered Hoodia has yet to be shown and may actually increase hunger. It's main use is as a cheap alternative to the more expensive weight loss herbs, which are the only alternative left after the banning of ephedra. Most supplement manufacturers can not use the more expensive weight loss herbs because it will result in a product that would be too expensive to compete with other more popular inexpensive diet supplements.

Hordenine appears naturally in many grains, grassy plants, and in some species of hallucinogenic cactus and it is related to the amino acid tyramine. By stimulating norepinephrine release it helps in achieving weight loss by liberating lipids from adipose tissue. It has a big effect over the central nervous system with its attributes of stimulant. It has active ingredients slowing down food digestion. The effect of this is the ability to go longer without meals because it gives a satiating effect. Also known as N.N. dimethyltyramine, Hordenine is actually an indirectly acting adrenergic substance that’s easily available and also acts as an excitatory hormone that energizes the body as well. Those who want to suppress appetite and increase their energy also benefit from this supplement.

L-Tyrosine is a proteinogenic polar amino acid, deemed not essential because it can be synthesized by the human body. As a member of the amino acid group that is being used by cells to build proteins, this building block derived its name from the Greek word tyros, which means cheese, because it was discovered in the cheese protein casein. L-Tyrosine can be synthesized from phenylalanine and can be found in foods high on protein, like soy products, poultry, cheese, bananas, dairy products and several seeds, including the sesame seeds. The unique phenol functionality and the occurrence in proteins that belong to the signal transduction process, make this amino acid different. Tyrosine can be converted by tyrosine hydroxylase enzyme into levodopa, a psychoactive drug that is used, among other uses, for clinical treatment of Parkinson’s disease. It is also involved in the synthesis of dopamine, norepinephrine and epinephrine.

Octopamine is a secretion initially discovered in the salivary glands of the Octopus and hence the derivation of the name. it tendso to act as a neurotransmitter, transmitting messages from the neurons to the brain and vice versa. Octopamine has been found to have a tendency to release fat deposits from cells, thus aiding in the loss of weight. It is therefore being used as a slimming agent by most people, even though there is no concrete evidence that it does assist in weight loss, for sure. Octopamine is also believed to increase blood pressure levels when it is in combination with other weight loss stimulating supplements. Although not much is known about Octopamine, a deeper study is being conducted into its uses and effects.

Pantothenic Acid is widely used for its effective use to treat acne. It is also used to relieve pain caused by rheumatoid arthritis and to relieve morning stiffness. Deficiency of Pantothenic acid is rare but can cause nausea, fatigue, headache and skin abnormalities. It plays a key role in the metabolism of carbohydrates and fats to release energy. It is also vital in antibody formation which helps in building immune system and preventing infections.

Synephrine, More commonly called "bitter orange" or Citrus Aurantium, which is taken from unripe oranges. Research shows that citrus aurantium can increase the metabolic rate without affecting heart rate or blood pressure, breaks down fat, burns calories and may act as an appetite suppressant.

Vinpocetine is a derivitate of the periwinkle plant and was developed in the latter part of the 1960’s. It can be used as a dietary supplement, which can be found online.

White Willow Bark is used as an anti-inflammatory and treats pains such as joint pain, flu, fever, back pain and osteoarthritis.

Yerba Matte or Ilex paraguariensis commonly grows in South America. It contains about twenty four vitamins and minerals, fifteen amino acids, eleven types of polyphenols, caffeine, and contains a high level of antioxidants. It is considered to be the most balanced stimulant and revered as the “drink of the gods”. It contains xanthine alkaloids such as theobromine, caffeine and theophylline, and saponins that stimulate the immune system, enhance the memory and focus, and suppress appetite. Yerba Mate also helps regulate the blood sugar and cholesterol level. It also helps burn the fat and fight free radical damages to cells that may cause cancer and aging. It also helps in cleansing the blood, and may act as a diuretic