Bioperine is an extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) that contains 95 percent of piperine. Black pepper is a common household spice. Extract from black pepper has also been used extensively as a medicine. To reach the greatest quality during the harvest, the pepper is reaped before ripening and after that is placed to dry under the sun rays. Bioperine is known for its effect to enhance the efficiency of many supplement nutrients. Bioperine acts to enhance the body’s natural therogenic activity – giving the name thermonutrient. This enhancement brings about increased metabolic rate creating demand for supple of many nutrients such as vitamins, minerals, herbals, amino acids. It sets in motion a process that brings about better digestion and faster gastrointestinal absorption.

Caffeine is a central nervous system stimulant that temporarily wards off drowsiness and boosts alertness and energy.

Synephrine or oxedrine is a drug derived from bitter orange or Citrus aurantium. It is an aromatic compound with the systematic name 4-[1-hydroxy-2-(methylamino)ethyl]phenol which indicates that it has an attached hydroxyl group at para position and a methyl amino group at another position. It is not one of those compounds on which an extensive scientific study has been done. However, it has some positional isomers such as the neosynephrine as well as other compounds. Studies indicate that it could act as a Beta-3 adrenergic receptor which means that if taken as a supplement it enhances the breakdown of fat to release energy and also increases heat production in the muscles.

Synthetic Guggulsterones, which is a form of orally administered guggulipid, which increases T3 (tryiidothyronine) levels in animal models. T3 is the conversion product of T4, which is produced by the thyroid gland. Thyroid hormone levels are closely involved in metabolic function. Increased thyroid levels can cause more fat to be burned and stored. While on a diet, the body responds by decreasing T3 levels, therefor decreasing metabolic rate. It is not known how guggulipid increases T3 levels. Guggul, also called guggulipid, is an ethyl acetate extract of the gum resin of the guggul tree.

Yohimbe is an alkaloid and the active ingredient of a medicinal herb also known as Pausinystalia yohimbe, formerly named Corynanthe yohimbe. It is noted as a stimulant drug and also as an aphrodisiac. While the medicinal community has conducted numerous studies of yohimbe in conjunction with sexual dysfunctions, in veterinary medicine, yohimbine is employed as the antidode to anesthesia stemming from the drug xylazine in large and small animals. In recent times, yohimbine has been found to instigate fat loss in athletes when taken orally. There are also some formulations available, for a significant price, where yohimbine can be directly applied transdermally to adipose tissue, leading to a local reduction. This application is still in experimentation and should not be used without professional assistance.