Bioperine is an extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) that contains 95 percent of piperine. Black pepper is a common household spice. Extract from black pepper has also been used extensively as a medicine. To reach the greatest quality during the harvest, the pepper is reaped before ripening and after that is placed to dry under the sun rays. Bioperine is known for its effect to enhance the efficiency of many supplement nutrients. Bioperine acts to enhance the body’s natural therogenic activity – giving the name thermonutrient. This enhancement brings about increased metabolic rate creating demand for supple of many nutrients such as vitamins, minerals, herbals, amino acids. It sets in motion a process that brings about better digestion and faster gastrointestinal absorption.

Caffeine is the most widely available legal psychoactive stimulant drug. Also known as theine, methyltheobromine and trimethylxanthine, this xanthine alkaloid is not only found in coffee beans, but also in guaranine that is derived from guarana, mateine derived from mate, theine which is found in various teas and the kola nut, which is the base flavor of various Cola soft drinks. It stimulates the central nervous system, where it restores alertness and wards off drowsiness. Caffeine is also know to display certain diuretic properties, is an ergogenic, an atagonist of the adenosine receptors, and a cAMP levels increasing factor. It seems that caffeine helps prevent the onset of Parkinson’s disease and in the long run lowers the possibility of developing a heart disease.

Synephrine or oxedrine is a drug derived from bitter orange or Citrus aurantium. It is an aromatic compound with the systematic name 4-[1-hydroxy-2-(methylamino)ethyl]phenol which indicates that it has an attached hydroxyl group at para position and a methyl amino group at another position. It is not one of those compounds on which an extensive scientific study has been done. However, it has some positional isomers such as the neosynephrine as well as other compounds. Studies indicate that it could act as a Beta-3 adrenergic receptor which means that if taken as a supplement it enhances the breakdown of fat to release energy and also increases heat production in the muscles.

Synthetic Guggulsterones improve the metabolism by increasing the thyroid hormones that influences the triiodothyronine (T3) hormones. It also activate the lypolytic enzymes the helps the burning of fats. Synthetic Guggulsterones is effective for weight loss without raising the heart rate. It also helps maintain the ideal cholesterol level within the normal range. It decreases the LDL cholesterol and triglyceride (TG) levels. Synthetic Guggulsterones also acts as a potent anti-inflammatory agent because of its myrrhanol A content. It also helps reduce acne because it contains tetracycline that is commonly used as an antibiotic in treating acne. It also reduces oxidative stress by decreasing the lipid peroxidation.

Yohimbe is an alkaloid and the active ingredient of a medicinal herb also known as Pausinystalia yohimbe, formerly named Corynanthe yohimbe. It is noted as a stimulant drug and also as an aphrodisiac. While the medicinal community has conducted numerous studies of yohimbe in conjunction with sexual dysfunctions, in veterinary medicine, yohimbine is employed as the antidode to anesthesia stemming from the drug xylazine in large and small animals. In recent times, yohimbine has been found to instigate fat loss in athletes when taken orally. There are also some formulations available, for a significant price, where yohimbine can be directly applied transdermally to adipose tissue, leading to a local reduction. This application is still in experimentation and should not be used without professional assistance.