Caffeine may be the most popular legal addictive stimulant that is available to mankind. Besides coffee, tea, guarana and kola nut have excess amount of this xanthine alkaloid, which is actually acting as a psychoactive drug. In several plants, caffeine is an effective insect repellant, but this trimethylxanthine is deemed by the Food and Drug Administration as generally safe food substance. It is an antagonist of adenosine receptors. The effect of caffeine is individual and may more or less increase the ability to perform physical and mental labor. It reduces the effects of fatigue and may in long term help predominantly men reduce the risk of developing Parkinson’s disease. It has also been observed that caffeine has nootropic effects, furthermore, regular consumption of caffeine may significantly reduce the risk of heart diseases.

Rhodiola Rosea Extract can help increase resistance against fatigue and can reduce stress. Classified as adaptogens among the herbs, it prevents different harmful impacts caused by physical and mental stress and illness. Rhodiola Rosea is particularly helpful for athletes because of its adaptogenic properties and its capability to enhance efficiency of mitochondrial respiration in skeletal muscle. It also improves mental work capacity and resists mental fatigue. Research has found that it helps protect against cancer. It can also be beneficial for people who suffer from high altitude sickness. Its intake can better endurance exercise capacity in young people and may also benefit people suffering from certain kinds of glucose level and cardiac conditions. Rhodiola Rosea Extract helps prevent ischemic brain damage development.

Taurine is found in high levels in the human heart and skeletal muscles. It is an amino sulfonic acid which is also present in the central nervous system and white blood cells. The human body produces this essential acid naturally so that it helps in absorbing vitamins and digesting fats. This acid reduces the problem of high blood pressure in adults and it is also being used for treating bipolar depression. Popularly known as a health supplement, Taurine has always been used in various health products. Bodybuilders are recommended to take Taurine along with creatine as it can prevent muscle soreness and fatigue. This amino acid is listed as one of the main supplemental ingredients in various energy drinks. For instance, drinks such as Rockstar and Monster, contain approximately 2000 mg of Taurine.

Vinpocetine, a derivative alkaloid of vincamine, is actually semi synthetic in nature. It is an extract from the It is an extract from the periwinkle vinca minor. Vinpocentine is used because it has neuroprotective effects and also helps in enhancing the cerebral blood flow. In Eastern Europe, it is also used as a drug to treat cerebrovascular disorders along with age related memory impairment. It is also extensively marketed as a supplement for vasodilation. It is also used to improve the memory since it plays the role of a nootropic. Vinpocentine is therefore used in supporting brain function. It helps in enhancing concentration and memory by activating cerebral metabolism. In the body building world, vinpocetine is often used a vasodilator. However, no research has been done so far on the effect of vinpocentine in the body building.

Vitamin B12, also known as cobalamin, which is naturally found in foods such as fish, milk and milk products, eggs, meat and poultry. Vitamin B12 is important for good health, necessary for the proper digestion and absorption of foods and for normal metabolism of carbohydrates, and fat. It helps maintain healthy nerve cells and red blood cells and is needed to make DNA. Vitamin B12 is bound to the protein in food. Hydrochloric acid in the stomach releases B12 from protein during digestion. Unlike other water-soluble nutrients, vitamin B12 is stored in the liver, kidney, and other body tissues. It can take several years before signs of the deficiency appear due to poor dietary intake. Vitamin B12 functions as a "methyl donor." A methyl donor is a compound that carries and donates methyl groups to other molecules, including cell membrane components and neurotransmitters. As a methyl donor vitamin B12 is involved in homocysteine metabolism and plays a critical role in proper energy metabolism, immune function, and nerve function. Therefore, vitamin B12 is clearly an added benefit for anyone wanting to lose weight, as without it, metabolism is not at its peak potential.

Vitamin B3, commonly called Niacin, exists in two main forms, niacin and niacinamide. The niacin form produces a flushing and itching of the skin when taken at higher dosages and this feeling is only temporary.

Vitamin B6 is important to a healthy human diet and is equally important in various metabolic and synthesis functions as well as gene expression.

Vitamin B9, which is also known as folate, pteroyglutamic acid, or folacin, belongs to the B complex group, which is vital for metabolic processes in the body. It decreases levels of amino acid homocysteine in the body, ensuring protection against heart ailments. It also reduces the risk of neural tube and other birth defects like cleft lip and palate, and various congenital heart defects. It provides protection against different forms of cancer and heart disease. It is beneficial in treatment of megaloblastic anemia. It also works as a coenzyme in transfer of formyl and hydroxymethyl groups in various biological systems, and in carbon metabolism. It assists the body in getting rid of homocysteine, a blood toxin affecting heart muscle and making cholesterol deposit in heart muscle. It also prevents stroke and heart attack.